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[41]Arias, Diego G

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In their study EMT-related protein E-cadherin was upregulated, while N-cadherin and vimentin were downregulated in B7-H3 silenced cells compared to negative controls

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When combined, these overlapping side effect profiles may worsen GI tolerability, particularly during the dose escalation phase when tirzepatide GI effects are already at their peak

JAMA 300 , 509519 (2008)