Epitalon effects on melatonin production and circadian rhythm typically persist for 4 to 6 months after a 10 to 20 day cycle, which is why cycles are repeated only 2 to 3 times per year
It may be used to lighten dark spots, hyperpigmentation, and irregular skin color and to even out an irregular complexion, making the skin look even and even brighter
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J Immunol 143:197481, PMID: 2789253 Markovic J, Borrs C, Ortega A, Sastre J, Via J, Pallard FV (2007) Glutathione is recruited into the nucleus in early phases of cell proliferation
(2007) Central role of p53 in the suntan response and pathologic hyperpigmentation
For broader context on aging biology and metabolic decline research, the NIH National Institute on Aging provides authoritative resources on the metabolic changes and epigenetic mechanisms that underlie age-associated obesity and sarcopenia