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This failure of PERK inhibition as a cancer therapeutic was expected since both mice and humans with a genetic loss of PERK suffer from rapid -cell death (Harding et al

ADASYN similarly improved performance compared to Borderline-SMOTE, but was slightly less effective than SMOTE-ENN, with RF, GBoost, and KNN, maintaining high AUC (0.9580.990) and balanced metrics, while simpler models showed moderate gains

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