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This distinction becomes clinically relevant for anyone with MASLD, elevated liver enzymes, or metabolic syndrome components beyond obesity

It is currently in Phase 3 trials, and FDA approval is not expected until late 2026

In addition, said Pham, Theres definitely a need for caution when scheduling surgery for patients on GLP-1 agonists because the medications effects on gastric motility can cause havoc from an anesthetic safety standpoint, she said

Frana-Pinto A, Mendes FA, de Carvalho-Pinto RM, Agondi RC, Cukier A, Stelmach R, Saraiva-Romanholo BM, Kalil J, Martins MA, Giavina-Bianchi P, et al

For a 220-pound person, thats 33 pounds with semaglutide versus 53 pounds with retatrutide

Approval is not automatic