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A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking

Also, animals fed a high-fat diet have been shown to have increased OxS and dysfunctional mitochondria (136)

Interestingly, in chronically insulin treated 3T3-L1 cells and fat explants from insulin resistant mice, only insulin-stimulated glucose uptake is decreased while insulin suppression of lipolysis is intact (121), effects which are explained by selective insulin resistance in adipocytes

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