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Transepidermal water loss is increased, and the barrier ability to keep irritants and pathogens out is reduced

While this supports immune cell activation and enhances pathogen clearance, excessive activation may contribute to tissue injury and immunosuppression (52)

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Research in dogs with liver disease has documented altered liver glutathione concentrations, supporting the idea that antioxidant systems may be under different pressure in hepatic conditions

This distinction matters because tesamorelin has body composition relevance, but it should not be marketed as a general fat-loss peptide

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