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However, the efficiency of the retinal redox system decreases significantly with age, increasing vulnerability to oxidative damage over time

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There was no need to evaluate the inconsistency between the direct (any class of drugs vs another class) and indirect (any class of drugs vs placebo) effects in the network meta-analysis, as there was no trial that compared any two classes in all the trials

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doi: 10.1093/jnci/dju246 128 ClynesDJelinskaCXellaBAyyubHScottCMitsonMet al