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This state of oxidative stress is a fundamental reason why many of the chronic diseases that shorten our lifespan take hold

They also have an increased risk of cholangiocarcinoma [223]

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Clinical Epigenetics, 7(1), 14

We also generated a construct in which LaccID was targeted directly to the Golgi compartment

57 GSH depletion occurred without a change in GSSG, suggesting efflux of GSH out of the glia, perhaps with additional increased conversion of GSH to GSSG in response to increased hydrogen peroxide formation