did tirzepatide get discontinued Zepbound (Tirzepatide) for Weight Loss shows changes in HbA1c over

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Naturally occurring variation in GLP1R cannot replicate that level of activation, which is why we don't see GLP1R variants with dramatic effects on BMI

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Not below normal, just normal

20 , 28 Even though cagrilintide activated a lesser number of neurons than sCT in the AP, NTS and LPBN, it resulted in similar metabolic effects as sCT on day 1 of injection suggesting that the metabolic effects cannot be predicted by quantitative activation