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Toxic solvent residues DMF (dimethylformamide) Known liver toxin Associated with reproductive toxicity Must be removed to extremely low limits in GMP drugs DCM (dichloromethane / methylene chloride) Probable human carcinogen Central nervous system depressant Dangerous even in small amounts if injected TFA (trifluoroacetic acid) Corrosive Can remain in peptides as unmeasured TFA salt Pharmaceutical products often convert TFA salts to safer counterions Without validated HPLC, mass spectrometry, and residual solvent testing, patients may be injected with harmful chemical contaminants
Curcumin stimulates the secretion of GLP-1 from gastrointestinal L-cells 7,8 resulting in insulin secretion and a hyperglycemic effect in humans 35
J Clin Endocrinol Metab 61 : 639643 Vasilcanu D, Girnita A, Girnita L, Vasilcanu R, Axelson M, Larsson O (2004) The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor
Sakurabayashi T, Takaesu Y, Haginoshita S et al (1999) Improvement of myocardial fatty acid metabolism through L-carnitine administration to chronic hemodialysis patients
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