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The change in peak area should have a linear relationship with the mass concentration of glutathione, with a goodness of fit (R) reaching 0.9995 or above

The review would benefit from a bit more text on how this notion impacts the balance between desired therapeutic effects, "diluted" effects from dimer-mediated versus non-dimer effects, and undesired off-target effects (which are discussed some in terms of receptor specificity, but not in terms of anatomy, where the same dimer may have different effects in different brain regions). Response: We have added a new section title General treatment approaches before the concluding remarks

All the authors have read the manuscript and proved it for publication

The complexation of PURE G4 -LA 12 with siRNA was performed as previously described [33]

Expect redness and swelling of the treated area, which will subside in 48h