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CLINICAL TRIAL EVIDENCE FOR DUAL GLP-1/GLUCAGON RAs AND TRIPLE AGONISTS IN MASH Survodutide Survodutide, a weekly dual GLP-1/GCG agonist, was assessed in a phase 2 dose-finding trial (NCT04771273) including 293 individuals with histologically confirmed MASH and fibrosis stages F1-F3 [46]

Injection-site reactions are very common

These molecules are particularly unsuitable for episodic or rescue indications via oral delivery, where rapid and reliable onset is essential

CagriSema is cagrilintide + semaglutide , a fixed-dose once-weekly combination developed by Novo Nordisk and studied in the REDEFINE program ( REDEFINE 1, NCT05567796 )

Y.RavichandranS.et al (2009)