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High-throughput screening campaigns against the GLP-1 receptor and other class B GPCRs consistently yielded low hit rates for small molecules, and the few hits that emerged typically showed micromolar potency, insufficient for therapeutic applications

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According to Kerry-Dene Ihlenfeldt, Clinical Director at IVBOOST UK, that shift reflects a broader change in how people think about fitness

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Every confident statement about KLOWs synergy is an extrapolation stacked on top of four separate bodies of evidence, three of which are preclinical and one of which is cosmetic