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[4] [5] Current evidence indicates: CoQ10 is generally well-tolerated with a favourable safety profile Serious adverse effects are rare Most reported side effects, including headaches, are mild and transient There is no established causal link between CoQ10 and headaches in the majority of users Individual responses vary considerably In the UK, CoQ10 products are generally sold as food supplements regulated under food law, not as licensed medicines

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doi: 10.3390/nu12051275 69

doi: 10.1016/j.cotox.2017.10.003

Ann.Thorac.Surg

Moreover, the G-RHEA@Gel group displayed the highest CD206 staining and the lowest CD86 signal, further validating that O 2 liberation and AST synergistically induced M2 polarization of macrophages