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Chrononutrition in Cardiometabolic Health
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10.1016/j.biopha.2021.112448 41 DucaF
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Concrete examples of biased agonism that have clearly improved therapeutic outcomes include the development of -arrestinbiased angiotensin II receptor ligands (which showed reduced hypertension-related adverse effects in preclinical models) and carfentanil-class opioid analogs designed to preferentially engage G-protein over arrestin pathways, thereby reducing respiratory depression (Schmid et al., 2017)
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