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Although pharmacological compounds aimed at inducing ferroptosis, such as erastin and RSL3, or inhibiting it, such as ferrostatin-1 (fer-1), have demonstrated potential in preclinical studies, their application in clinical settings faces challenges, including off-target effects and limited tissue specificity [2,3,4,5,6]

2024 [cited 2024 Apr 24];16

Vegetables: Cruciferous vegetables like broccoli, Brussels sprouts, and cauliflower, as well as other fiber-rich vegetables, contribute to the production of butyrate

There are a few treatments still in the experimental phase which hold future promise for the therapy of HE (Table 3) such as Minocycline, which reduces microglial cell activation in cerebral insult and results in a reduction of brain edema as well as plasma and CSF ammonia levels

M., Picardi P

Sex-based differences in susceptibility to severe acute respiratory syndrome coronavirus infection