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The risk for hyperammonemia with topiramate appears dose related and has been reported more frequently when concomitantly used with valproic acid [see Drug Interactions (7)]

Macrophage activation and foam cell formation may explain the elevated CRP serum levels and contribute to disease progression (Figure 3)

A systematic review and meta-analysis published in JAMA Internal Medicine in 2022 pooled 76 randomized clinical trials covering 103,371 patients and found that randomization to a GLP-1 receptor agonist was associated with an increased risk of gallbladder or biliary disease (relative risk 1.37

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Jankowski CM, Gozansky WS, Schwartz RS, Dahl DJ, Kittelson JM, Scott SM,