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Serious Vascular Complications (Nicolau Syndrome) This pertains to a rare but devastating ischemic necrosis following injection

If oxidative stress is sufficient and antioxidants are not, mitochondria are shut down to avoid cell lysis and ATP is down regulated, limiting synthesis of aldosterone and cortisol (Atanassova & Koeva, 2012)

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If you draw 2.1mL instead of 2.0mL, your concentration drops from 2.5mg/mL to approximately 2.38mg/mL