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Because this peptide naturally circulates in the human bodyand its levels decline with agethe risk of immunological reactions or toxicity remains virtually negligible

Early continuous inhibition of group 1 mGlu signaling partially rescued dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome [133]

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According to the classic two-hits model, the increased insulin resistance, secondary to metabolic syndrome, determines an excessive lipid accumulation in healthy hepatocytes (first hit), mainly through an increased mobilization of free fatty acids from visceral adipose tissue to the liver

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