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Abnormalities in selenium metabolism and skeletal development diseases Selenium deficiency is regarded as one of the initiating factors of KBD, which is an endemic osteoarthropathy caused by the premature closure of epiphyseal plate and the impaired skeletal development

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In the randomized controlled trial carried out by Glauser and colleagues, it was found that initial monotherapy with VPA for children with newly diagnosed childhood absence epilepsy exerted superior efficacy for seizure control without unsatisfactory adverse events compared to other AED such as lamotrigine [156]

doi: 10.1038/nchembio.2238 21 KimJHLewinTMColemanRA

Total Tau and phosphorylated Tau protein serum levels in patients with schizophrenia compared with controls