AuNP-based colorimetric assay has been used for the detection of various substances including small molecules, DNA, and proteins [79]
The convergence of biosensing, wireless communication, and materials engineering is paving the way for self-regulating platforms that sense pathological cues and initiate on-demand therapy
We confirmed that GCLC-KO mice have significantly reduced GCLC and glutathione levels, and an elevated ratio of oxidized to total glutathione in their brains (Fig
It directly quenches reactive hydroxyl free radicals, other oxygen-centered free radicals, and radical centers on DNA and other biomolecules
Oncogene 26(28):4148-4157, 2007
Therefore, the precise mechanisms through which lipoxygenases contribute to ferroptosis, particularly in GPX4 inhibition contexts, require further investigation ( 3.2.4 Therapeutic targets and experimental evidence Lipid peroxidation not only affects biological membrane fluidity and membrane protein function, impairing cellular activity, but its products also form reactive aldehyde end products, including 4-hydroxynonenal (4-HNE) and MDA