Additional Contrave warnings Contrave has a black box warning
Multi-Pathway Healing Mechanism Upregulates VEGF expression to stimulate new capillary formation in injured tissue
Available evidence strongly suggests the opposite, that tirzepatide is actively supporting kidney health through multiple pathways including reduced inflammation, improved metabolic function, and decreased albuminuria
Marwick, Nitesh Nerlekar Nature Reviews Cardiology.2026;[Epub] CrossRef A review of cutting-edge biomarkers for diagnosing coronary artery disease Pouria Azami, Sahand Mohammadzadeh, Soroush Seirafi, Iman Razeghian-Jahromi Medicine.2025
While effective, the weight loss achieved with GLP-1s is generally less than that seen with bariatric surgery
There is also one interaction worth knowing rather than guessing: tirzepatide's prescribing information advises anyone on oral contraceptives to use a back-up or non-oral method for 4 weeks after starting and after each dose increase