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Consistently, our MD simulations found that the -carboxylate spacer stably inserted into the TM1-TM2 cleft and the 16-carbon palmitic chain is deeply buried in the receptor-lipid interface, contributing massive contacts to stabilize the complexes (Fig
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One in three women undergoing axillary lymph node dissection and radiotherapy will develop this incurable and disabling disease ( As far back as 1957 studies have shown that obesity can increase the risk of secondary lymphedema ( Glucagon-like peptide 1 receptor agonists (GLP-1RAs) were originally brought to market as treatments for diabetes, and were noted to induce weight loss ( Although weight loss has been reported to be beneficial in the treatment of lymphedema, no studies to date have examined the use of GLP-1RAs for the treatment of secondary lymphedema
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