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Sestrin2-mediated suppression of mTORC1 and mTORC2 activation reprograms lipid metabolism to limit ATP and NADPH consumption, thereby enabling cancer cells to survive under glutamine-depleted conditions

Immunoblot of indicated proteins in HEK-293T SLC25A39 knockout cells expressing a vector control or SLC25A39 cDNA treated with BSO (1 mM) for the indicated times

Participants also reported vomiting and constipation

Assigning that to MC4R, or MC1R, requires either a system expressing only one receptor subtype, or selective antagonist controls, or a selective agonist comparator run in parallel

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Faster gastric emptying typically reduces early satiety and may increase appetite, which is the opposite of weight loss mechanisms seen with GLP-1 agonists that slow gastric emptying