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In the context of cytosolic and mitochondrial fatty acid synthesis, not only is CoA required, but so too is the intermediate in CoA synthesis, 4-phosphopantetheine

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Thiamine deficiency in causes neurological injury leading to the Wernicke/Korsakoff syndrome ( FIGURE 2 via effects on homocysteine/methionine metabolism as well as DNA methylation

doi: 10.3389/fphar.2015.00308 162 DeyPSinghJSuluvoyJKDilipKJNayakJ

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