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GLP-1 use is growing every year and expanding to treat a wide range of conditions beyond obesity and diabetes, including noncirrhotic MASH

Additionally, DPP-4 inhibitors such as linagliptin inhibit the receptor for Advanced glycation end products (RAGE) expression in keratinocytes, which can facilitate local vitamin D production by preventing interference from accumulated Advanced glycation end products (AGEs, 142)

Collectively, the integrated therapeutic strategies targeting ferroptosis, pyroptosis, and necroptosisincluding RCD inducers combined with ICIs, nanotechnology-driven precision delivery systems, and multi-targeted approaches to overcome metabolic plasticity and off-target toxicitiesprovide a comprehensive framework to enhance melanoma immunotherapy efficacy ( Figure 4 )

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Having megaloblastic anemia can make you more at risk of suffering from osteoporosis, problems with your vision, struggle with memory, worsened cognitive functioning, and if you were to become pregnant, it increases the risk of birth defects in the fetus