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Pathway enrichment analysis of these differentially prevalent metabolites revealed significant perturbations in metabolic networks including branched-chain aminoacids degradation, glutathione metabolism, threonine and 2-oxobutanoate degradation, gluconeogenesis, pyruvate metabolism, and glycine and serine metabolism (Figure S5)

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Randomized controlled trials, observational studies, including case control studies, prospective cohort study, retrospective observational study, reviews, and meta-analysis were including if reference was made to apolipoproteins and atherosclerotic coronary plaques

The findings add to a growing body of scientific evidence raising public health concerns about the long-term impacts of diets high in ultra-processed products