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Front Pharmacol 29(12):646287

They slow the rate at which food leaves the stomach, reduce glucagon secretion (which lowers blood sugar), and act on reward centers in the brain to reduce cravings

Final thoughts Research shows that switching from semaglutide to tirzepatide is a strategic way to improve weight loss and/or blood sugar outcomes

Nutrition protocol during transition Maintain the eating patterns you established on tirzepatide, even when appetite increases temporarily

Patients should be educated about serious adverse effects requiring immediate medical attention, including: Pancreatitis: severe abdominal pain radiating to the back, persistent vomiting Hypersensitivity reactions: rash, difficulty breathing, facial swelling Gallbladder disease: right upper quadrant pain, fever, jaundice Thyroid C-cell tumors (boxed warning): neck mass, dysphagia, hoarseness, persistent dyspnea Regular follow-up with healthcare providers ensures appropriate monitoring and timely intervention if adverse effects occur

To validate, intranasal delivery of MSC-derived exosomes reduced extracellular plaque, inflammation, and glial activation in a mouse model of AD