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Glucagon receptor activation causes more gastrointestinal distress than GIP activation, which partly explains why survodutide has higher discontinuation rates in clinical trials compared to tirzepatide
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520 Subsequently, the study observed that treatment with liraglutide, both in vitro (cell culture models) and in vivo (mouse models), inhibited the tumor formation and metastatic capabilities of pancreatic cancer cells by activating GLP-1R
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