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Second, semaglutide, the active ingredient in oral Wegovy, has been on the market for years

So I was like, wow, okay

A 68-week randomised controlled trial of semaglutide in adults with overweight or obesity (without diabetes) found that while approximately 39% of the total weight lost was lean mass, this was within an acceptable clinical range and mostly proportional to the degree of total weight loss [4]

Phase 2 trials included over 700 participants with follow-up periods up to 26 weeks

One suggested practice to managing GI AEs is the Three Es method, which comprises 1) education and explanation, 2) escalation to an appropriate dose, and 3) effective management of GI AEs