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Its glucagon receptor activity also makes it a subject of interest in hepatic fat research independent of body weight effects

FIGURE 10 3.6 Validation of the expression of GLP-1 signaling-related genes in CRC tissues Subsequently, we performed protein-protein interaction network analysis among 42 genes related to GLP-1 signaling (Supplementary Figure S1) and selected top 10 genes with highest node-degree for further validation in CRC tissues (Supplementary Table S2)

The study showed that orforglipron led to significant weight changes in participants, especially at the highest dose

That works out to 28.7% of their body weight

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