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Janssen I, et al

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The main characteristic of PD is the reduction or disappearance of dopaminergic neurons in the substantia nigra (SN), with the depletion of dopamine in the striatum and the emergence of Lewy bodies with -synuclein aggregation as main components

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That is also why early side effects can show up before the antidepressant benefit is fully established

The digestive system breaks them down before meaningful amounts reach circulation