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In addition to immunomodulatory and anti-inflammatory effects, butyrate is also the main energy source of intestinal epithelial cells, which can induce mucus production and strengthen the tight connection between cells together with thyroid hormone, playing an important role in maintaining the intestinal barrier [40]

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After SFN application, subjects (n = 30) were topically exposed to alcohol, and reddened skin area was measured as indicator of SFN protection against irritation

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