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Gene expression and phosphorylation of AANAT (the rate-limiting enzyme in melatonin synthesis) become downregulated

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10.1007/s00109-016-1488-y 46 HuangT.ZhangK.SunL.XueX.ZhangC.ShuZ.et al (2015)

This contraindication applies specifically to neonates and does not extend to adults at the concentrations present in standard reconstitution volumes