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It is a recombinant form of the peptide exendin-4, which is a GLP-1 receptor agonist with a 53% similarity to the gastrointestinal hormone GLP-1 and it is resistant to DPP-4 inactivation with a 140-minute half-life after subcutaneous administration allowing therapy by a twice daily administration [36]

Umapathysivam MM, Lee MY, Jones KL, Annink CE, Cousins CE, Trahair LG, et al

Alcohol and GLP-1 drops Drinking alcohol while on semaglutide or tirzepatide is a topic that generates significant debate

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Alternative Antidiabetic Drugs Selection In the first method, selecting alternative antidiabetic drugs to decrease insulin dosage requires evidence of the drugs safety and potential PDA risk

N Engl J Med 2021;385:50315.ArticlePubMed 91