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Given the heterogenic nature of NAFLD, targeting metabolic, anti-inflammatory, or anti-fibrotic disease pathways simultaneously may exert an additive or synergistic effect and combination therapy may prove to be a an important tool in the future development of pharmacological treatment options

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Additionally, liraglutide treatments delayed disease onset and decreased the median clinical score from 5 to 2 in animal models (p = 0.0003) [23]

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The metabolic changes come from cellular-level effects rather than artificially elevated sympathetic tone