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Liver toxicity has resulted with use of nicotinic acid (750 milligrams/day) and nicotinamide (10 grams/day) supplements

Interesting proposals, which could be developed in the future, are epithelial regeneration via stem cells or epithelial growth pathways (EGFR), or the enhancement of tight junctions integrity via inhibition of myosin light-chain kinase (MLCK), whose activity correlates with postprandial intestinal permeability

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Subspecialists may pursue newer medical therapies, such as lubiprostone (Amitiza), which acts on chloride channels in the intestine, 36 or onabotulinumtoxinA (Botox) injected into a nonrelaxing sphincter

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WADA Prohibited List (2025), Section S2: Peptide Hormones, Growth Factors, Related Substances and Mimetics (Insulin-like Growth Factor-1 and its analogues)