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VEGF is up-regulated during hypoxia and orchestrate blood vessel formation mainly via activation of VEGF receptor-2 (VEGFR-2) expressed by endothelial cells [120]

Obes Rev (2022) 23(suppl 1):e13389

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With subcutaneous injection, these central and peripheral effects occur simultaneously because the peptide distributes throughout the body via systemic circulation

The most common side effects may include nausea, constipation, diarrhea, bloating, heartburn, fatigue, and decreased appetite

The best combo imo. Discussions occurred on the r/PeptideForum subreddit, too, with guys wanting to up their doses to see even better results