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This covalent modification disrupts the Keap1-Nrf2 complex, liberating Nrf2 to translocate to the nucleus

An experimental drug from Lilly, eloralintide, led to an average 11.3% weight loss over 12 weeks in a Phase 1 study, according to new results published last week at the diabetes conference

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doi: 10.1093/ajcn/79.6.935, 51