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However, ototoxicity has been reported as a potential serious side effect related to high-dose administration

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Nevertheless, this procedure encounters significant challenges, such as the potential contamination of ovarian tissue with malignant cells, which heightens the risk of tumor recurrence (67)

The focus of this section is to review evidence related the impacts of RT-induced IGF-1 on brain health and not to imply that more circulating IGF-1 is better