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Reduce the dose if symptoms persist

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By blocking NNMT-mediated consumption of nicotinamide, 5-Amino-1MQ redirects nicotinamide back into the NAD+ salvage pathway

Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

They serve as the building blocks of proteins and play crucial roles in biological processes

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