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Separate studies demonstrated anti-anxiety effects in rats at remarkably low doses (0.5 mg/kg), with effects appearing within 12 minutes and including increased exploration of open and lighted spaces, a standard measure of reduced anxiety in rodent models

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Wilsons Disease or other copper metabolism disorders are absolute contraindications because the additional copper delivery could cause dangerous accumulation

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A was associated with greater depressive symptoms (left parietal cortex) and poorer visual-spatial memory (left temporal cortex) before treatment, but was not correlated with improvement with citalopram treatment [338]

Because everyones environmental toxic load and baseline nutrient levels are different, individual results will vary significantly