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Sweating it out with intense exercise, however, is probably not the best idea since you might already be dehydrated and lightheaded

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GLP-1 plays a key role in regulating blood sugar, appetite, and insulin secretion

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This finding may contribute in part to the explanation for why the combination of agonists targeting both the GIP and GLP-1 systems has yielded promising results in preclinical models and clinical trials, providing greater body weight loss and better glycemic control than GLP-1R agonism alone (25,5457)