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In addition, the KD upregulates genes related to muscle atrophy, such as Mafbx , Murf1 , Foxo3 , Lc3b , and Klf15 , to reduce muscle mass, fiber cross-sectional area, and grip strength (67)

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Participants received single ascending doses (0.512 mg) or multiple ascending doses (0.512 mg weekly)

One liter of saline and B vitamins