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In a study on hepatocellular carcinoma (HCC), Zip2 and Zip9 were upregulated in M2-polarized macrophages, while Zip9 was slightly downregulated in M1-polarized macrophages

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Results demonstrate that nanomolar concentrations of KPV inhibit NF-kappaB and MAP kinase inflammatory signaling pathways, leading to a reduction in pro-inflammatory cytokine secretion