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It is not simple

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Abstract Traditionally, Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs), a pivotal class of drug, mimics the actions of endogenous Glucagon-like peptide-1, which have been found to be remarkable in the treatment of type 2 diabetes alongside other comorbidities

Only 15.3% of included studies reported whether patients experienced GI side effects with additional symptoms, and 6.8% serious GI complications like pancreatitis and severe nausea and vomiting (exclusively in studies of GLP-1 receptor agonists)

A variety of GLP-1RAs and analogues, such as exendin-4 and liraglutide, has been used successfully in the treatment of type 2 diabetes mellitus (T2DM) (2)