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The GLP1 receptor agonist revolution is here
TB-500 (Thymosin Beta-4) Phase I and Phase II safety trials of intravenous thymosin beta-4 published in human cohorts (Ruff et al., 2010)
It functions by imitating the natural hormone GLP-1, which tells the pancreas to make more insulin when blood sugar levels are high
In mouse models of E/I dysfunction, GABA_B receptor agonists like arbaclofen have been shown to restore aspects of the E/I balance, resulting in improved behavioral deficits ( Histopathologically, while GABA supplementation helped in preserving some aspects of hippocampal structure, significant neurodegeneration and reduced neuron density remained, particularly in the CA4 region, similar to what was observed in the PPA-treated group
The mechanisms are complementary, not redundant
FDA-approved Selective Estrogen Receptor Modulators Inhibit Ebola Virus Infection
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