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The formula includes Akkermansia muciniphila - with preclinical research demonstrating GLP-1 secretion via the P9 protein mechanism - and HOWARU Shape B420 - with a published randomized controlled trial associated with changes in body fat mass and waist circumference in overweight adults
Therefore, considering significance of both NO-system and egr-1 gene-systems for inflammatory bowel disease (54) as well as for multiple sclerosis (55-57), these may be important also when confronted with severe complications of advanced and poorly controlled IBD as well as multiple sclerosis
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8), that was consistent with its established neurotoxic effects in rodent models 55,56 .This cytokine dysregulation suggests a mechanistic link between MSG-induced neuroinflammation and cognitive deficits, and emphasize the critical role of neuroinflammatory cascades in mediating excitotoxicity-induced neurodegeneration 101,102
