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A clinical trial for the pill showed that participants who took the full course of treatment over 64 weeks experienced an average weight loss of around 17%, compared to 3% weight loss in a placebo group

[DOI] [PubMed] [Google Scholar] [52].Prausnitz MR, Microneedles for transdermal drug delivery, Adv Drug Deliv Rev 56(5) (2004) 5817

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In terms of effectiveness, both treatments can lead to significant weight loss, but Wegovy has a longer track record and is generally considered slightly more effective overall, while orforglipron (Foundayo) offers greater convenience as a simpler daily pill

A patch cannot provide this level of dosing precision

This broader targeting allows retatrutide to potentially offer greater weight loss and metabolic benefits