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Vitamin B12 injections (hydroxocobalamin in the UK) are prescribed for documented deficiency states such as pernicious anaemia and malabsorption disorders

10.1089/acm.2006.12.881 Summary Keywords vitamin B12, efficacy, bioavailability, therapeutic approaches, meta-analysis, cobalamin Citation Mazur M, Ndokaj A, Salerno C, Vallone J, Ardan R, Bietolini S, Carrouel F, Wilk A, Sarig R, Ottolenghi L and Bourgeois D (2025) Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis

For vitamin B12, this relatively modest daily requirement reflects the body's efficient recycling mechanisms and the vitamin's storage capacity in the liver, which can maintain reserves for several years (typically 2-5 mg)